Investigation of Keyes skin biopsy instrument for intestinal biopsy versus a standard biopsy technique.

A prospective, clinical trial was conducted using 12 dogs that were presented for intestinal biopsy. Comparisons were made between paired jejunal biopsies collected using a Keyes biopsy punch and a standard scissor excisional technique. There were no differences in speed of collection, diagnostic value of specimens, complication rates, or sample quality.

Ocular melanoma in a Long Evans rat.

During a long-term study, a rat exposed to half-amplitude band pass fluorescent blue light (434 to 475 nm) and receiving a calcium channel blocker developed an ocular mass. By visual examination, a presumptive diagnosis of ocular melanoma was made. Subsequent surgical removal of the eye, followed by histopathology, confirmed the lesion as a highly pigmented epitheliod melanoma.

Characterization of monoclonal antibodies directed to canine T lymphocyte markers expressed during development.

Two monoclonal antibodies (mAb) which recognize cell surface antigens of canine T lymphocytes are described. mAb RQ1 (of IgG1 subclass) binds a 34 kDa peptide under non-reducing conditions which is expressed, on average, by 27 +/- 9% (n = 11 dogs) of thymocytes, with preferential binding for medullary, but not cortical thymocytes. RQ1 adheres to splenic periarteriolar lymphoid sheath cells.