Synthesis of 1-azaspiro[4.4]nonan-1-oxyls via intramolecular 1,3-dipolar cycloaddition.

Sterically shielded nitroxides of the pyrrolidine series have shown the highest resistance to reduction. Here we report the synthesis of new pyrrolidine nitroxides from 5,5-dialkyl-1-pyrroline -oxides via the introduction of a pent-4-enyl group to the nitrone carbon followed by an intramolecular 1,3-dipolar cycloaddition reaction and isoxazolidine ring opening. The kinetics of reduction of the new nitroxides with ascorbate were studied and compared to those of previously published (1,2,3',4',5',2″)-dispiro[(2-hydroxymethyl)cyclopentan-1,2'-(3',4'-di--butoxy)pyrrolidine-5',1″-(2″-hydroxymethyl)cyclopentane]-1'-oxyl ().

Combined Effect of Silver Nanoparticles, Ceftriaxone, and Methyluracil during Experimental Purulent Peritonitis.

Bacterial biofilms provoke and/or promote the most chronic and recurrent infectious diseases. Previously, experimental models of purulent peritonitis and meningoencephalitis revealed positive antibiofilm effect of metallic nanoparticles and the absence of resistance against such nanoparticles in microorganisms. This study examines the combined effect of silver nanoparticles with ceftriaxone and methyluracil on recovery mechanisms during inflammatory diseases exemplified by purulent peritonitis in experimental animals.

[Scientific, pedagogical, and surgical work of professor V.F.Voyno-Yasenetsky during the Great Patriotic War].

The article is devoted to activities in the period 1941-1945. Krasnoyarsk and Tambov, a professor of surgery Valentine Feliksovich Voyno-Yasenetsky (Archbishop Luka)--doctor of medical sciences, laureate of the State (Stalin) Prize of the USSR, who made a significant contribution to the success of modern surgical science. A brilliant scholar and successor of the ideas of the outstanding scientist and surgeon Nikolai Pirogov, as in the Great Patriotic War surgeon and consultant evacuation hospitals, along with leading surgeons in the Soviet Union had a significant impact on the results of treatment of wounded soldiers and officers, thereby affecting the development of military field surgery.

[Medical service of the Red Army in Vislo-Oder strategic offensive].

Was characterized work of medical service of the Red Army in Vislo-Oder strategic offensive. To the beginning of the operation in divisions of the first echelon were deployed medical aid stations in dugouts and blindages in 1.5-3 km from the front line.

[Medical service of Russian Army in the First World War 1914-1918 (to the 95th anniversary of the beginning of war)].

During the First World War 1914-1918 Russian Army hadn't a united medical service, military-medical affair was diluted in multiple governances. Evacuation of wounded and ill persons was an affair of Evacuation Governance of Main Governance the General Staff. Process of treatment in field and stationary medical formations was administered by sanitarium chiefs of armies and theaters of operation, bureaucrats of Russian Red Cross Society, Russian Union of Cities and Territorial Union.