Publications by authors named "P G Corn"
Background: To determine outcomes of MRI-assisted radiosurgery (MARS) for salvage brachytherapy using the radioisotope Pd after various upfront treatments including surgery, external beam radiotherapy, and brachytherapy.
Methods: We retrospectively reviewed data for patients who underwent salvage MARS for intraprostatic lesions or prostate bed recurrences from 2016 to 2022. Biochemical recurrence, prostate cancer-specific, and overall survival, and the cumulative incidences of toxicities, were determined by Kaplan-Meier estimates.
Article Synopsis
- Therapeutic resistance in cancer, especially in advanced prostate cancer, contributes to high mortality as patients often relapse after initial treatments.
- Research on circulating tumor cells with increased genomic content (CTC-IGC) from 44 advanced prostate cancer patients reveals a link to poorer survival outcomes and clonal origins, indicating polyploidization.
- Identification of new RNA and protein markers associated with chemotherapy resistance, such as HOMER1, TNFRSF9, and LRP1, suggests pathways for improving cancer treatment and understanding relapse mechanisms.
Therapeutic resistance in cancer significantly contributes to mortality, with many patients eventually experiencing recurrence after initial treatment responses. Recent studies have identified therapy-resistant large polyploid cancer cells in patient tissues, particularly in late-stage prostate cancer, linking them to advanced disease and relapse. Here, we analyzed bone marrow aspirates from 44 advanced prostate cancer patients and found the presence of CTC-IGC was significantly associated with poorer progression-free survival.
View Article and Find Full Text PDFHormone therapy (HT) to treat prostate cancer is reported to cause adverse changes in body composition. Clinically, interpatient body composition changes are heterogeneous, but the biological and clinical determinants of body composition toxicity are unknown. Herein, we test the hypothesis that inherited polymorphisms in steroidogenic genes are associated with differential changes in body composition after HT.
View Article and Find Full Text PDFWhole-body magnetic resonance imaging for staging patients with high-risk prostate cancer.
Prostate Cancer Prostatic Dis
September 2024
Background: Staging patients with high-risk prostate cancer (HRPCa) with conventional imaging of computed tomography (CT) and bone scintigraphy (BS) is suboptimal. Therefore, we aimed to compare the accuracy of whole-body magnetic resonance imaging (WBMRI) with conventional imaging to stage patients with HRPCa.
Methods: We prospectively enrolled patients with newly diagnosed HRPCa (prostate-specific antigen ≥20 ng/ml and/or Grade Group ≥4).