Alzheimer's disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway.

Background: Neurodegenerative disorders, including Alzheimer's disease (AD), have been linked to alterations in tryptophan (TRP) metabolism. However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. This study aimed to investigate transcriptomic, DNA methylomic (5mC) and hydroxymethylomic (5hmC) changes within genes involved in the TRP and nicotinamide adenine dinucleotide (NAD) pathways in AD, using three independent cohorts.

The full picture of people's realities must be considered to deliver better diets for all.

Efforts to address poor-quality diets have stepped up considerably in recent years, but the problem of inadequate, unhealthy, unsustainable and unequal diets persists. Here we argue that to get policies and interventions working more effectively and equitably, a fresh approach is needed-one that considers the full picture of people's realities. People's realities interact to shape the way people respond to and engage with policies and interventions, thereby influencing their impact, particularly, albeit not only, on dietary inequalities.

Intellectual humility is reliably associated with constructive responses to conflict.

Conflict is a ubiquitous, but potentially destructive, feature of social life. In the current research, we argue that intellectual humility-the awareness of one's intellectual fallibility-plays an important role in promoting constructive responses and decreasing destructive responses to conflict in different contexts. In Study 1, we examine the role of intellectual humility in interpersonal conflicts with friends and family members.

Pili Pono Practice: A Qualitative Study on Reimagining Native Hawaiian Food Sovereignty through MALAMA Backyard Aquaponics.

Living in one of the most remote island chains in the world, Native Hawaiians developed sophisticated food cultivation systems that sustained a thriving and robust population for centuries. These systems were disrupted by colonization, which has contributed to the health disparities that Native Hawaiians face today. MALAMA, a culturally grounded backyard aquaponics program, was developed to promote food sovereignty among Native Hawaiians.