Publications by authors named "P G Arnold"
Shrews are among the most speciose of mammalian clades, but their evolutionary history is poorly understood. Their fossil record is fragmentary and even the anatomy of living groups is not well documented. Here, we incorporate the oldest, most complete fossil shrew yet known into the first phylogenetic analysis of the group to include molecular, morphological and temporal data.
View Article and Find Full Text PDFPharmacogenetics-predicted drug metabolism may not match clinically observed metabolism due to a phenomenon known as phenoconversion. Phenoconversion can occur when an inhibitor or inducer of a drug-metabolizing enzyme is present. Although estimates of phenoconversion in adult populations are available, prevalence estimates in youth populations are limited.
View Article and Find Full Text PDFIn radiology, technological progress has led to an enormous increase in data volumes. To effectively use these data during diagnostics or subsequent clinical evaluations, they have to be aggregated at a central location and be meaningfully retrievable in context. Radiology data warehouses undertake this task: they integrate diverse data sources, enable patient-specific and examination-specific evaluations, and thus offer numerous benefits in patient care, education, and clinical research.
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- Very large sample sizes are essential for studying autism, and data sharing among diverse studies can help create a unified dataset through data harmonization, which aligns scores from different assessment tools.
- The study used data from over 700 participants, comparing scores on two adaptive functioning measures (VABS and ABAS) and employed multiple regression techniques to predict VABS scores using ABAS scores and other demographic factors.
- Results revealed significantly higher VABS scores in the autism group compared to the ABAS scores, with age being a key factor, and all regression techniques performed similarly in predicting outcomes, highlighting the importance of ABAS score, diagnosis, and age in the prediction model.
Article Synopsis
- Rare earth tris(alkyl) complexes, like M(CHSiMe)(sol), are commonly used as catalysts in polymerization and functionalization processes, but their thermal instability limits their practical applications.
- This study introduces a new series of more stable rare earth neosilyl solvates, based on a comprehensive investigation of their decomposition mechanisms, specifically for Sc(iii), Y(iii), Lu(iii), and Sm(iii) complexes.
- The findings reveal that simply using higher-denticity donors does not prevent decomposition effectively, as unexpected pathways arise, and small amounts of LiCl impact the stability of certain complexes, leading to a novel method for producing pure Y(r)(THF) without relying on the lithium salt.