Publications by authors named "P Fuss"
Context: Observational studies suggest that low vitamin D status may be a risk factor for cancer.
Objective: In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, we sought to determine if vitamin D supplementation lowers the risk of cancer and precancers.
Methods: The Vitamin D and type 2 diabetes (D2d) cancer outcomes study (D2dCA) is an ancillary study to the D2d study, which was conducted at 22 academic medical centers in the United States.
Background: Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin D supplementation lowers the risk of diabetes is unknown.
Methods: We randomly assigned adults who met at least two of three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; plasma glucose level 2 hours after a 75-g oral glucose load, 140 to 199 mg per deciliter; and glycated hemoglobin level, 5.
Evidence on biological plausibility from mechanistic studies and data from observational studies suggest that vitamin D may be linked to risk of several types of cancer. However, evidence from clinical trials evaluating the effect of vitamin D supplementation on cancer risk is limited. The Vitamin D and Type 2 Diabetes (D2d) study is a multi-center, randomized, placebo-controlled clinical trial conducted to examine the causal relationship between oral vitamin D supplementation and development of diabetes among overweight adults with prediabetes.
View Article and Find Full Text PDFAssociation between environmental exposure and CD4+CD25+ regulatory T cells.
Allergol Immunopathol (Madr)
April 2019
Background: It is considered that farm areas protect young patients from allergy and asthma due to high exposure to endotoxins.
Aim: To compare CD4+/CD25+ T-regulatory cells and forkhead transcription factor Foxp3 expression in asthmatic children allergic to house dust mites (HDM) living in rural and farm areas.
Materials And Methods: This was a prospective analysis of 35 children living in farm areas (n=19) and rural areas (n=16), aged 8-16, with allergic rhinitis (allergic to dust mites) and newly diagnosed asthma.
Article Synopsis
- The CALERIE study was the first randomized trial to investigate the effects of calorie restriction (CR) on health in nonobese humans, focusing on aerobic capacity (V˙O2max) and muscle strength.
- In the study, 218 participants were divided into a CR group (25% reduction in calorie intake) and a control group, with measured outcomes showing weight loss in the CR group and variable impacts on V˙O2max and strength.
- Results indicated that while absolute measures of V˙O2max and muscle strength decreased in the CR group, when adjusted for body mass, these values improved, suggesting that moderate CR may not negatively affect aerobic capacity in healthy adults.