Publications by authors named "P Fruekilde"
Long-term sample stability of five atypical antipsychoticdrugs risperidone, paliperidone, clozapine, quetiapine and olanzapine and the antidepressant drug mirtazapine in serum was studied by use of a newly developed and validated analytical method based on solid-phase extraction and liquid chromatography-tandem mass spectrometry. Ascorbic acid was used as an antioxidative agent to stabilize olanzapine during storage and sample preparation. We assessed analyte stability on long-term storage in serum samples at 25°C, 5°C, -20°C and -80°C, and during five freeze-thaw cycles.
View Article and Find Full Text PDFArticle Synopsis
- - A study was conducted to assess substance use (including alcohol and nicotine) in pregnant women in Denmark, as there is limited verified data on this topic.
- - The research involved urine samples and questionnaires from nearly 1900 pregnant women attending ultrasound scans; results showed that 25% tested positive for substances, with a confirmed prevalence of 10.8% for all substances, predominantly nicotine usage.
- - The findings indicated that while self-reporting of nicotine was high, reporting for alcohol and cannabis was notably low, highlighting discrepancies between self-reported data and actual substance use detected through screening.
Background: In 2020, the European Medicines Agency recommended testing patients for dihydropyrimidine dehydrogenase (DPD) deficiency before systemic treatment with fluoropyrimidines (FP). DPD activity testing identifies patients at elevated risk of severe FP-related toxicity (FP-TOX). The two most used methods for DPD testing are DPYD genotyping and DPD phenotyping (plasma uracil concentration).
View Article and Find Full Text PDFDihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between -genotype variants and P-uracil concentrations.
Acta Oncol
November 2022