GWAS-Assisted and multi-trait genomic prediction for improvement of seed yield and canning quality traits in a black bean breeding panel.

In recent years, black beans (Phaseolus vulgaris L.) have gained popularity in the U.S.

Genome-wide association and genomic prediction for iron and zinc concentration and iron bioavailability in a collection of yellow dry beans.

Dry bean is a nutrient-dense food targeted in biofortification programs to increase seed iron and zinc levels. The underlying assumption of breeding for higher mineral content is that enhanced iron and zinc levels will deliver health benefits to the consumers of these biofortified foods. This study characterized a diversity panel of 275 genotypes comprising the Yellow Bean Collection (YBC) for seed Fe and Zn concentration, Fe bioavailability (FeBio), and seed yield across 2 years in two field locations.

Thulium Fiber Laser Versus Holmium:Yttrium Aluminum Garnet for Lithotripsy: A Systematic Review and Meta-analysis.

Context: Thulium fiber laser (TFL) emerged as a competitor of holmium:yttrium aluminum garnet (Ho:YAG) laser for the treatment of urinary stones.

Objective: To compare the efficacy between Ho:YAG and TFL for laser lithotripsy of renal and ureteral stones.

Evidence Acquisition: A literature search was conducted using PubMed/Medline, Embase, and Web of Science databases to identify reports published until May 2023.

Amyloid plaques and normal ageing have differential effects on microglial Ca activity in the mouse brain.

In microglia, changes in intracellular calcium concentration ([Ca]) may regulate process motility, inflammasome activation, and phagocytosis. However, while neurons and astrocytes exhibit frequent spontaneous Ca activity, microglial Ca signals are much rarer and poorly understood. Here, we studied [Ca] changes of microglia in acute brain slices using Fluo-4-loaded cells and mice expressing GCaMP5g in microglia.