Publications by authors named "P Frommolt"
Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation of BAT is well understood, the rheostatic regulation of BAT to avoid excessive energy dissipation remains ill-defined. Here, we demonstrate that adenylyl cyclase 3 (AC3) is key for BAT function.
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- Auditory synaptopathy/neuropathy (AS/AN) is a type of hearing loss where sound detection in the cochlea works fine, but the inner ear’s sound encoding is disrupted, often due to genetic or environmental reasons.
- A study identified a specific mutation linked to AUNA2, a form of auditory neuropathy, in a German family, discovering a significant deletion in a gene called ATP11A on chromosome 13q34.
- This deletion of ATP11A, which is important for moving certain lipids in cells, affects its function and contributes to hearing issues in both humans and a mouse model, helping to clarify the genetic basis of this disorder.
Regulation of cellular metabolism is now recognized as a crucial mechanism for the activation of innate and adaptive immune cells upon diverse extracellular stimuli. Macrophages, for instance, increase glycolysis upon stimulation with pathogen-associated molecular patterns (PAMPs). Conceivably, pathogens also counteract these metabolic changes for their own survival in the host.
View Article and Find Full Text PDFObesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation induced lncRNAs in mouse liver. Similarly, lncRNAs are lost in diabetic humans.
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