Hormone therapy and cancer risks in transgender people: a systematic review.

Objective: To identify the available evidence on the risk of developing cancer in transgender people undergoing hormone therapy.

Methods: This was a rapid systematic review conducted in the PubMed, Embase, Virtual Health Library, Cochrane Library and Epistemonikos databases. Screening and data extraction were performed by independent reviewers using the Rayyan platform.

Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms.

Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms.

Experimental validation of XPM mitigation using a generalizable multi-task learning neural network.

We address the development of efficient neural network (NN)-based post-equalizers in long-haul coherent-detection dense wavelength-division multiplexing (DWDM) optical transmission systems. To achieve a high level of generalization of the NN-based equalizers, we propose to employ multi-task learning (MTL). MTL refers to a single shared machine learning (NN) model that can perform multiple different (albeit related) tasks.

L-tyrosine methyl ester hydrochloride crystal under high pressure and DFT calculations.

The methylated organic salt L-tyrosine methyl ester hydrochloride (LTMEHCl) crystal was synthesized by the slow solvent evaporation method. The crystal structure was verified through Powder X-ray Diffraction. Three-dimensional periodic Density Functional Theory calculations (DFT) were conducted to identify the Raman active modes.