Publications by authors named "P Freedman"
Four versions of the novel Moletest on-device signal-processing analysis software, delivered on a single-application iPadPro11, were evaluated in pigmented skin lesions of patients sent for biopsy comparing its results with the lesion histology. The primary objective was to demonstrate that the nomela test provided at least 95 ± 2% sensitivity for not-melanoma. Proprietary software recognised the lesion perimeter, rejecting images with uncertain border, and performed analysis using non-scalar metrics of the image within the perimeter.
View Article and Find Full Text PDFSomatic mitochondrial DNA (mtDNA) mutation accumulation has been observed in individuals with retinal degenerative disorders. To study the effects of aging and mtDNA mutation accumulation in the retina, a polymerase gamma (POLG) exonuclease-deficient model, the Polg mutator mice (D257A), was used. POLG is an enzyme responsible for regulating mtDNA replication and repair.
View Article and Find Full Text PDFArticle Synopsis
- * The cytokine IL-41, initially linked to adipose tissue, has been found to have immunomodulatory properties and was studied for its levels in blood and skin biopsies of SSc patients.
- * Findings revealed lower levels of IL-41 in patients with diffuse SSc, suggesting it may act as an antifibrotic agent, while elevated levels of a related protein, mTOR, were noted in the skin of these patients.
Two cases of imatinib induced oral pigmentation affecting the palate.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Background: Medication-related oral pigmentation is a unique yet benign finding in the dental setting. As new antineoplastic agents emerge, it is likely that this documented manifestation will continue to grow.
Case Description: Here, we describe two case presentations of imatinib-related hyperpigmentation of the palate.
Article Synopsis
- Malakoplakia is a rare inflammatory disorder mainly seen in immunocompromised patients, characterized by an inability of macrophages to effectively kill bacteria.
- Although it usually occurs in the genitourinary and gastrointestinal regions, this report highlights a rare case where malakoplakia affected the maxilla and maxillary alveolar ridge mucosa, marking a unique instance of oral cavity involvement.
- Diagnostic stains revealed specific patterns indicating malakoplakia without evidence of microbial infection, emphasizing the need for clinicians and pathologists to consider this condition when evaluating lesions in immunosuppressed patients.