Publications by authors named "P Fragu"
The aim of this study was to determine therapy-related risk factors for the development of melanoma after hemangioma. A cohort study was conducted among 4620 patients treated before 16 years of age for skin hemangioma in France. A nested case-control study was also conducted on 13 patients who developed a melanoma (cases) matched with five controls in cohort according to sex, age at the hemangioma diagnostic, the calendar year of occurrence of the hemangioma, and follow-up.
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- This cohort study explored the link between childhood radiation treatment for skin hemangiomas and the development of thyroid cancer and adenomas in later life.
- Among the 4,767 patients analyzed, 11 developed thyroid carcinoma and 44 developed adenomas over an average follow-up of 35 years, with a significant correlation between radiation dose to the thyroid and cancer risk.
- The findings suggest that past radiation exposure increases the likelihood of thyroid issues, highlighting the need for careful monitoring of patients who received such treatments.
The story of thyroid calcitonin is an illuminating example of the voyage of hormone from a therapeutic tool for bone disease to a tumour marker to screen for subclinical forms of cancer. Identified as a new thyroid hormone implicated in calcium metabolism, its pharmacological action offered a new therapeutic tool for the management of bone disease. By measuring the circulating calcitonin, a range of values was obtained for oncologists because the evolution of a newly identified form of thyroid cancer--medullary (MTC)--was poorly understood.
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- A study looked at the long-term effects of radiation treatment on young patients who had a skin condition called hemangioma between 1940 and 1973.
- Out of over 7,000 patients, many were treated with radiotherapy and some died of cancer later on, especially those who received a specific type of radiation called (226)Ra.
- The results suggest that kids treated with this radiation may have a higher chance of dying from cancer, so it's important to keep an eye on these patients in the future.
How the field of thyroid endocrinology developed in France after World War II.
Bull Hist Med
September 2003
This microhistory analyzes the transformation of French medical practice after World War II. Before the 1940s, coordinated clinical and experimental studies on a patient with thyroid disease were nonexistent. Starting in 1945, thyroid endocrinology was pushed forward by the use of radioiodine, which led pediatricians to rethink the hereditary transmission of thyroid diseases, stimulated by the school of biochemistry headed by Jean Roche, who participated in the elucidation of thyroid-hormone metabolism.
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