Publications by authors named "P Forsythe"

Background: Pregnancy and childbirth are accompanied by widespread maternal physiological adaptations and hormonal shifts, that have been suggested to result in a period of vulnerability for the development of mood disorders such as postpartum depression (PPD). There is also evidence of peripartum changes in the composition of the gut microbiota, but the potential contribution of intestinal microbes to the adaptations, or subsequent vulnerabilities, during this period are unknown.

Summary: Here we outline key pathways involved in peripartum adaptations including GABAergic signaling, oxytocin and immunomodulation that are also associated with susceptibility to mood disorders and present evidence that these pathways are modulated by gut microbes.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on pulmonary neuroendocrine cells (PNEC), which are important yet rare cells in the airway that may influence allergic asthma, and introduces a new in vitro model to study their functions in response to allergens like house dust mite (HDM).
  • - Researchers created PNEC cultures from human stem cells and primary bronchial cells, exposing them to various stimuli (HDM, Bergamot oil, and LPS) to measure changes in gene expression and neuropeptide release.
  • - Findings showed that HDM specifically triggered an increase in the CALCB gene and the release of the neuropeptide CGRP, highlighting PNEC's role in the neuroendocrine response to allergens, which can
View Article and Find Full Text PDF

It is important to have reliable information on the presence/absence, population structure, and density of animals across their natural range. Detecting small organisms, however, such as the Nearctic tree trunk sheetweaver spider Drapetisca alteranda Chamberlin 1909 (Araneae: Linyphiidae), presents challenges due to its diminutive size and cryptic nature. We used a capture/recapture study to determine the detection and recapture probabilities of this spider using a standard beat sheet technique adopted for surveying tree trunks.

View Article and Find Full Text PDF

Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse physiological processes that decline with age. Gut to brain vagus firing patterns are regulated by myenteric intrinsic primary afferent neuron (IPAN) to vagus neurotransmission. It remains unclear how IPANs or the afferent vagus age functionally.

View Article and Find Full Text PDF