1,4-d-Sorbitan: A Promising Biobased-Platform for the Synthesis of Chiral Amines.

The regio- and diastereoselective synthesis of chiral amines derived from 1,4-d-sorbitan has been developed the borrowing hydrogen reaction using a cooperative catalysis between an achiral iridium catalyst and diphenylphosphoric acid. The different reactivities of the four hydroxyl groups on the 1,4-d-sorbitan scaffold have also been highlighted.

Collaborative care versus screening and follow-up for patients with diabetes and depressive symptoms: results of a primary care-based comparative effectiveness trial.

Objective: Depressive symptoms are common and, when coexisting with diabetes, worsen outcomes and increase health care costs. We evaluated a nurse case-manager-based collaborative primary care team model to improve depressive symptoms in diabetic patients.

Research Design And Methods: We conducted a controlled implementation trial in four nonmetropolitan primary care networks.

Functional and structural age-related changes in the scalp skin of Caucasian women.

Background: Ageing of the skin, being chronological or sun induced is highly documented. Scalp, as a specific skin site, has, however, received little attention. This work attempted to describe functional and structural alterations that occur in scalp skin with ageing.

Controlled trial of a collaborative primary care team model for patients with diabetes and depression: rationale and design for a comprehensive evaluation.

Background: When depression accompanies diabetes, it complicates treatment, portends worse outcomes and increases health care costs. A collaborative care case-management model, previously tested in an urban managed care organization in the US, achieved significant reduction of depressive symptoms, improved diabetes disease control and patient-reported outcomes, and saved money. While impressive, these findings need to be replicated and extended to other healthcare settings.

Psychiatric evaluation of the agitated patient: consensus statement of the american association for emergency psychiatry project Beta psychiatric evaluation workgroup.

It is difficult to fully assess an agitated patient, and the complete psychiatric evaluation usually cannot be completed until the patient is calm enough to participate in a psychiatric interview. Nonetheless, emergency clinicians must perform an initial mental status screening to begin this process as soon as the agitated patient presents to an emergency setting. For this reason, the psychiatric evaluation of the agitated patient can be thought of as a 2-step process.