Publications by authors named "P Flodr"
Background: Despite bevacizumab being the first biological agent approved for the treatment of metastatic colorectal cancer (mCRC), there is not any established DNA biomarker to improve its efficacy and personalize the treatment.
Materials And Methods: Thirty patients with mCRC on bevacizumab therapy (15 with a good response and 15 with a poor response) from the University Hospital Olomouc were followed. Formalin-fixed paraffin-embedded (FFPE) samples were used for copy number variation (CNV) analysis using the OncoScan FFPE Assay Kit in order to capture approx.
Article Synopsis
- Amyloidosis is a rare disorder caused by misfolded proteins, leading to abnormal deposits in tissues, including the lungs, where nodular pulmonary amyloidosis is particularly uncommon and often asymptomatic.* -
- The only documented case of nodular pulmonary amyloidosis causing clinical symptoms, like spontaneous pneumothorax, involved an 81-year-old male with an AH-dominant type, highlighting its rarity and complexity.* -
- Accurate identification of amyloid types is challenging but essential for understanding the underlying disease and determining appropriate diagnostic and treatment strategies, making it important in differential diagnoses of pulmonary conditions.*
Epstein-Barr virus (EBV), defined as a group I carcinogen by the World Health Organization (WHO), is present in the tumour cells of patients with different forms of B-cell lymphoma, including Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and, most recently, diffuse large B-cell lymphoma (DLBCL). Understanding how EBV contributes to the development of these different types of B-cell lymphoma has not only provided fundamental insights into the underlying mechanisms of viral oncogenesis, but has also highlighted potential new therapeutic opportunities. In this review, we describe the effects of EBV infection in normal B-cells and we address the germinal centre model of infection and how this can lead to lymphoma in some instances.
View Article and Find Full Text PDFBackground: Lower gastrointestinal (GI) graft versus host disease (GVHD) represents a severe complication in allogeneic hematopoietic stem cell transplant (HSCT) recipients with high rates of transplant-related mortality. Deregulated innate immunity reactions are the features of its pathogenesis. Cellular senescence has been considered a program of the innate immunity.
View Article and Find Full Text PDFObjective: Case presentation and subsequent dia-gnostic and therapeutic procedure of autoimmune encephalitis caused by the presence of ovarian teratoma.
Case Report: We describe the case of a young woman with symptoms of an acute psychotic attack unresponsive to antipsychotic treatment. Anti-N-methyl-D-aspartate receptor encephalitis was dia-gnosed within the interdisciplinary cooperation at the University Hospital in Olomouc.