Publications by authors named "P Fleitas"
Background: Treatments for soil-transmitted helminthiases face challenges, especially in addressing Trichuris trichiura. Combination regimens, particularly of ivermectin and albendazole, are promising. We aimed to assess the safety, efficacy, and palatability of a combination tablet for the treatment of T trichiura, hookworm, and Strongyloides stercoralis infections among school-aged children in Ethiopia, Kenya, and Mozambique.
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- Trichuris trichiura is a parasitic worm causing intestinal issues, and the typical treatment is albendazole, which works better when combined with ivermectin.
- This article focuses on developing pharmacokinetic models and understanding how this drug combination works based on data from clinical trials involving healthy adults and infected children and adolescents.
- Findings showed both drugs had similar absorption characteristics, and the chosen dosages in the trial were deemed suitable for future testing in larger studies.
Soil-transmitted helminth (STH) infections account for a significant global health burden, necessitating mass drug administration with benzimidazole-class anthelmintics, such as albendazole (ALB), for morbidity control. However, ALB efficacy shows substantial variability, presenting challenges for achieving consistent treatment outcomes. We have explored the potential impact of the baseline gut microbiota on ALB efficacy in hookworm-infected individuals through microbiota profiling and machine learning (ML) techniques.
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