Publications by authors named "P Fields"
Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021.
View Article and Find Full Text PDFThe fossil record of the U.S. Pacific Northwest preserves many Middle Miocene floras with potential for revealing long-term climate-vegetation dynamics during the Miocene Climatic Optimum.
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- Genomic regions involved in parasite defense, like the MHC, are highly variable, with multiple factors like single nucleotide polymorphisms and copy number variations contributing to this diversity.
- The study focuses on the Pasteuria Resistance Complex (PRC) in the crustacean Daphnia magna, revealing significant genetic variation and non-homologous haplotypes, suggesting the region is under balancing selection and has a long evolutionary history.
- The research highlights the interplay of ancient resistance mechanisms and hyper-divergent genomic environments, offering insights into the evolution of disease resistance not just in Daphnia, but across the broader Cladocera class.
RNA sequencing (RNA-Seq) has become a widely adopted technique for studying gene expression. However, conventional RNA-Seq analyses rely on gene expression (GE) values that aggregate all the transcripts produced under a single gene identifier, overlooking the complexity of transcript variants arising from different transcription start sites or alternative splicing. Transcript variants may encode proteins with diverse functional domains, or noncoding RNAs.
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- Salinization is a growing global issue that impacts freshwater organisms like Daphnia magna, raising concerns about their adaptability to increasing salinity levels.
- Research showed that Daphnia populations with higher salt tolerance are better adapted to their native habitats, as evidenced by a correlation between local salinity and salt tolerance.
- A crucial gene, TPS, linked to trehalose production was identified as key to managing salinity stress, with experiments confirming that animals lacking functional TPS struggle to tolerate higher salinity.