Subtrochanteric Fractures of The Femur: May a Short Nail Be a Reliable Option?

Objectives: Treatment of subtrochanteric fractures of the proximal femur may be challenging due to their anatomical and biomechanical features. Intramedullary nails are the most frequently used devices, although there is no consensus concerning their optimal length. The aim of this study is to compare the functional and radiological outcomes of the fragility subtrochanteric fractures treated with short versus long cephalomedullary nails.

How to combine multiple tools for the genetic diagnosis work-up of pediatric B-cell acute lymphoblastic leukemia.

This study investigated the importance of comprehensive genetic diagnosis in pediatric B-cell acute lymphoblastic leukemia (B-ALL). We analyzed 175 B-ALL employing karyotyping, FISH, MLPA, targeted next-generation sequencing (t-NGS), and Optical Genome Mapping (OGM). This approach achieved an 83% classification rate, identifying 17 distinct genetic subtypes.

Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning.

The discovery of the optimal conditions for chemical reactions is a labor-intensive, time-consuming task that requires exploring a high-dimensional parametric space. Historically, the optimization of chemical reactions has been performed by manual experimentation guided by human intuition and through the design of experiments where reaction variables are modified one at a time to find the optimal conditions for a specific reaction outcome. Recently, a paradigm change in chemical reaction optimization has been enabled by advances in lab automation and the introduction of machine learning algorithms.

The nature of grief: implications for the neurobiology of emotion.

This paper explores the limitations of neurobiological approaches to human emotional experience, focusing on the case of grief. We propose that grief is neither an episodic emotion nor a longer-term mood but instead a heterogeneous, temporally extended process. A grief process can incorporate all manner of experiences, thoughts, and activities, most or all of which are not grief-specific.

Use of by-products from the industrial distillation of lavandin (Lavandula x intermedia) essential oil as effective bioherbicides.

Weeds are one of the main problems causing losses in agricultural crops, which are nowadays mainly combated by the massive use of chemical herbicides. The development of new effective, sustainable, environmentally and health-friendly bioherbicides is a fundamental need worldwide. In this work, hydrolates and lavandin distilled straws produced during the distillation of the essential oil of lavandin (Lavandula x intermedia) were tested as potential bioherbicides.