Publications by authors named "P Fennessey"
Article Synopsis
- Trimethylaminuria (TMAU) is a genetic disorder where individuals can't metabolize trimethylamine (TMA) due to mutations in the FMO3 gene, leading to a fishy odor because TMA is odoriferous while its oxidized form, TMAO, is not.
- The study evaluated ten individuals with odor complaints through sensory evaluation, urine analysis after choline ingestion, and whole exome sequencing to understand the genetic basis of TMAU.
- All subjects had impaired TMAO production, confirming TMAU, and genetic analysis revealed one had a rare FMO3 variant, while others showed common decreased-function variants and novel mutations, suggesting that other genetic factors may also contribute to TMAU.*
Purpose: To assess the outcome of patients with medically treated hyperhomocysteinemia (HHC) requiring intervention for critical limb ischemia (CLI).
Methods: A parallel observational study was conducted to compare the clinical and revascularization outcomes of CLI patients who received standardized treatment for HHC preoperatively (folic acid and vitamin B12) vs. contemporaneous patients with normal homocysteine levels.
Background: Individuals with the metabolic disorder trimethylaminuria may sporadically produce malodors despite good hygiene. The psychosocial impact of trimethylaminuria can be considerable. However, trimethylaminuria is difficult to diagnose without specialized tests, in part because odor production is diet-dependent, and malodors may not be present during medical examinations.
View Article and Find Full Text PDFThe role of ingested fat in the etiology of obesity is controversial. The aims of this study were to determine the contributions of ingested fat oxidation to: 1) 24-h total energy expenditure (TEE), and 2) substrate oxidation during acute stationary cycle exercises in adult humans. Healthy, moderately obese (n = 18; BMI = 31 +/- 1 kg/m2) subjects (8 men; 10 women) were each studied in a whole-room calorimeter for 24 h.
View Article and Find Full Text PDFReducing water to hydrogen gas by zinc or uranium metal for determining D/H ratio is both tedious and time consuming. This has forced most energy metabolism investigators to use the "two-point" technique instead of the "Multi-point" technique for estimating total energy expenditure (TEE). Recently, we purchased a new platinum (Pt)-equilibration system that significantly reduces both time and labor required for D/H ratio determination.
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