Publications by authors named "P Fenaroli"
Background: Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells but typically regarded as nonspecific "scar reaction." This study aimed to investigate the relationship between inflammatory fibrosis and kidney disease progression in LN.
Methods: Interstitial fibrosis and tubular atrophy (IFTA) were scored in 124 LN kidney biopsies.
Lipofilling has emerged as an effective technique in breast reconstruction for enhancing aesthetic outcomes and addressing residual deformities. Traditionally, fat grafting has been performed as a secondary step in implant-based breast reconstruction during the replacement of the expander with a breast implant or as a revisional procedure. Our study investigates the technical feasibility and presents preliminary results of a new promising technique for delivering fat grafting in a three-dimensional (3D) shape, directly during mastectomy with immediate breast reconstruction or in delayed breast reconstructive procedures.
View Article and Find Full Text PDFKey Points: Apolipoprotein L1 (APOL1)-G1 induced kidney disease in the two APOL1 transgenic mouse models, HIV-associated nephropathy and IFN- administration. Glomerular single-nuclear RNA-sequencing identified genes differentially expressed among mice with APOL1-G1 and G0 variants at single-cell resolution.
Background: Apolipoprotein L1 () high-risk variants contribute to kidney disease among individuals with African ancestry.
Article Synopsis
- * Recent research indicates that the connection between anti-dsDNA antibodies and kidney problems is weak, and it showcases a variety of other renal-targeting autoantibodies, including increased attention to the IgG2 isotype, which was previously overlooked.
- * New "second wave antibodies" have emerged, which play a role in modulating inflammation in the kidneys, suggesting they could be key in refining treatment strategies and monitoring therapeutic responses in LN patients.
Chronic kidney disease progresses through the replacement of functional tissue compartments with fibrosis, a maladaptive repair process. Shifting kidney repair toward a physiologically intact architecture, rather than fibrosis, is key to blocking chronic kidney disease progression. Much research into the mechanisms of fibrosis is performed in rodent models with less attention to the human genetic context.
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