Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohort.

Persistent organic pollutants (POPs) are a group of organic chemical compounds. Contradictory results have emerged in epidemiological studies attempting to elucidate their relationship with breast cancer risk. This study explored the relationship between dietary exposures to multiple POPs and ER-positive breast cancer risk in the French E3N cohort study, using three different approaches to handle multicollinearity among exposures.

Evidence of a positive association between dietary exposure to polychlorinated biphenyl (PCB) and weight gain among women in the E3N prospective cohort.

Background: Polychlorinated biphenyls (PCB) and dioxins are persistent organic pollutants found in food and known for their ability to bioaccumulate. Various animal studies have highlighted obesogenic effects related to the exposure to PCB and dioxins, nevertheless human studies have led to inconsistent results. The present study aims to investigate the associations between dietary intakes of PCB and dioxins and the risk of weight gain, overweight and obesity in the French E3N cohort (Étude Épidémiologique auprès de femmes de la mutuelle générale de l'Éducation Nationale).

Association between fish consumption and mortality in the E3N French women's cohort.

Western studies have shown a non-linear association between fish consumption and mortality, which might be explained by exposure to chemical contaminants. This study aims to explore the associations between fish consumption or omega-3 polyunsaturated fatty acids (n-3 PUFA) and mortality within the prospective E3N French cohort, and to investigate the role of dietary exposure to contaminants in these associations. In the E3N cohort composed of 72,585 women, we assessed fish consumption and n-3 PUFA intake through a food questionnaire sent in 1993.

Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort.

Aims/hypothesis: The aim of the present study was to investigate the association between dietary exposures to dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and the incidence of type 2 diabetes mellitus (T2DM) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods: This prospective cohort study with a median 11.7 years of follow-up, included 318,416 individuals recruited in 21 centers in eight countries.