Correlation between p53 immunoexpression and TP53 mutation status in extrapulmonary small cell neuroendocrine carcinomas and its association with patient survival.

Extrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Despite its morphological similarity to lung small cell carcinomas, its oncogenesis remains uncertain. One hundred and seventy-one EP-SCNC were enrolled in a multicenter study, and all tissue samples underwent an immunohistochemical p53 analysis.

Molecular and Immunohistochemical Classification of Extrapulmonary Small Cell Neuroendocrine Carcinomas: A Study of 181 Cases.

Extrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Most patients with EP-SCNC have metastatic disease upon presentation, and their average overall survival (OS) is less than 12 months. Our study aimed to conduct a complex analysis of EP-SCNC.

Long-range enhancers maintain competency for hair cell regeneration in the inner ear.

During tissue regeneration, lineage-related cells can switch their fate to replace missing cells. This cell plasticity is particularly prominent in more regenerative vertebrates such as zebrafish, yet the molecular basis by which cells transdifferentiate into another cell type upon injury remains unclear. Here, we investigate the epigenetic basis of regenerative transdifferentiation in the inner ear, where supporting cells (SCs) generate mechanosensory hair cells (HCs) upon damage.

Food Insecurity and Weight Faltering: US Multisite Analysis of Young Children's Weight Trajectory.

Background: Food insecurity is associated with poor health and development among young children, with inconsistent findings related to longitudinal growth.

Objective: The aim of this study was to investigate associations between household and child food insecurity and young children's weight trajectory during ages 0 to 2 years.

Design: Longitudinal survey data were analyzed for years 2009 to 2018.

Decadal trends and predictive insights into aquatic ecosystem health in the Namhan River, South Korea: Longitudinal analysis of hydro-environmental factors and stream health indices (2008-2022).

The main focus of this study is to explore the complex interactions between aquatic ecosystem health (AEH) and time-varying hydro-environmental factors. We measure AEH in the Namhan River of South Korea using stream health index (SHI) scores for the trophic diatom index (TDI), benthic macroinvertebrate index (BMI), and fish assessment index (FAI) for 2008 to 2022. Key hydro-environmental variables associated with AEH, including their time-lagged responses, are identified.