Publications by authors named "P F Worley"
Live human brain tissues provide unique opportunities for understanding the physiology and pathophysiology of synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization-while crucial parameters such as synaptic vesicle dynamics were not visualized. Here we utilize zap-and-freeze time-resolved electron microscopy to overcome this hurdle.
View Article and Find Full Text PDFBackground: General practice is pivotal in delivering mental health care within communities, yet the attitudes and professional factors influencing this provision remain underexplored. This study seeks to understand the perspective of general practice staff around the professional factors that influence the provision of primary mental health care.
Methods: A qualitative study was conducted with semi-structured interviews of 14 general practice staff involved in mental health care.
How to establish a new medical school? A scoping review of the key considerations.
Adv Health Sci Educ Theory Pract
September 2024
Establishing new medical schools in medically under-served regions is suggested as part of the solution to the problem of doctor shortages and maldistributions. Establishing a new medical school is, however, a complex undertaking with high financial and political stakes. Critically, the evidence-base for this significant activity has not previously been elucidated.
View Article and Find Full Text PDFArticle Synopsis
- - The study highlights the significant issue of type 2 diabetes in Aboriginal communities, particularly focusing on Ngarrindjeri Country in South Australia, and criticizes the prevalent Western biomedical frameworks that overlook local contexts and strengths.
- - Utilizing a combination of Aboriginal and Western research methods, the study collected qualitative data from 15 participants through yarning sessions, identifying barriers rooted in the impacts of colonization, as well as community strengths that support diabetes care.
- - The findings suggest that despite facing numerous challenges, Aboriginal people in the area possess unique resources and capabilities to combat diabetes, emphasizing the need for health initiatives that respect local knowledge and prioritize community-led, holistic approaches over traditional medical models.
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3 ligase, TRIAD3A, that functions as an autophagy adaptor for tau. TRIAD3A(RNF216) is an essential gene with mutations causing age-progressive neurodegeneration.
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