Publications by authors named "P F Semple"

Background: At Groote Schuur Hospital (GSH), the neurosurgical intensive care unit (NsICU) is a 6-bed unit headed by a specialist neurosurgeon with extensive experience in neurocritical care, working in close collaboration with intensivists from the Division of Critical Care. There is currently no detailed analysis of the demographics, diagnosis and management of patients admitted to the NsICU at GSH.

Objectives: To provide a detailed descriptive analysis of the demographics, diagnosis and management of patients admitted to the NsICU at GSH from 1 January 2020 to 31 December 2021.

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Strong lines of evidence in the neuroscience literature indicate that (a) healthy sleep facilitates cognitive processing, and (b) sleep disruption is associated with cognitive dysfunction. Despite the fact that patients with pituitary disease often display both disrupted sleep and cognitive dysfunction, few previous studies investigate whether these clinical characteristics in these patients might be related. Hence, we explored whether sleep disruption in patients with pituitary disease mediates their cognitive dysfunction.

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Introduction: Interprofessional disaster simulation exercises provide an opportunity for first responder students to learn about disaster response and recovery, to practice their roles and to learn to collaborate with other first responders. With the move to virtual education during the COVID-19 pandemic, a table-top disaster exercise is an alternative format to inperson exercises. To date, most disaster simulation exercises for students have focused on the roles of healthcare providers.

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Article Synopsis
  • The study details how a large state teaching hospital in South Africa responded to the COVID-19 pandemic by expanding their intensive care unit (ICU) capacity from 25 to 54 beds, facing various resource constraints.
  • Key elements for success included effective pre-planning, strong leadership, teamwork, and clear communication.
  • Despite increasing ICU admissions, the hospital faced a significant nursing staff shortage, and while a high flow nasal oxygen service helped reduce the need for ICU admissions, patients requiring intubation after failing this treatment had a poor prognosis.
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Article Synopsis
  • Up to 32% of COVID-19 pneumonia patients may need ICU care; this study focuses on those needing invasive mechanical ventilation (IMV) in South Africa.
  • A total of 461 patients were admitted over one year, with 380 meeting criteria and 377 having known outcomes; the median age was 51 years, and common comorbidities included diabetes and hypertension.
  • The study found a 30.8% hospital survival rate, with factors like male sex, older age, and higher SOFA scores linked to increased mortality risk.
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