Publications by authors named "P F Pinsky"
Background: Cancer screening trials have required large sample sizes and long time-horizons to demonstrate cancer mortality reductions, the primary goal of cancer screening. We examine assumptions and potential power gains from exploiting information from testing control-arm specimens, which we call the "intended effect" (IE) analysis that we explain in detail herein. The IE analysis is particularly suited to tests that can be conducted on stored specimens in the control arm, such as stored blood for multicancer detection (MCD) tests.
View Article and Find Full Text PDFBackground: Cancer screening trials have required large sample sizes and long time-horizons to demonstrate cancer mortality reductions, the primary goal of cancer screening. We examine assumptions and potential power gains from exploiting information from testing control-arm specimens, which we call the "intended effect" (IE) analysis that we explain in detail herein. The IE analysis is particularly suited to tests that can be conducted on stored specimens in the control arm, such as stored blood for multicancer detection (MCD) tests.
View Article and Find Full Text PDFArticle Synopsis
- Multicancer detection (MCD) tests use blood samples to look for multiple types of cancer at the same time, which might help catch cancers earlier, especially those that aren't easy to test for now.* -
- These tests are different from regular cancer screenings because they don't tell you where the cancer is, so more tests might be needed to figure that out.* -
- While MCD tests can find some cancers early, their accuracy varies, and there are concerns they might give false negatives, making people less likely to get regular check-ups.*
Importance: Randomized clinical screening trials have shown that sigmoidoscopy screening reduces colorectal cancer (CRC) incidence and mortality. Colonoscopy has largely replaced sigmoidoscopy for CRC screening, but long-term results from randomized trials on colonoscopy screening are still lacking.
Objective: To estimate the additional screening benefit of colonoscopy compared with sigmoidoscopy.