Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa.

During the large Ebola outbreak that affected West Africa in 2014 and 2015, studies were launched to evaluate potential treatments for the disease. A clinical trial to evaluate the effectiveness of the antiviral drug favipiravir was conducted in Guinea. This paper describes the main challenges of the implementation of the trial in the Ebola treatment center of Guéckédou.

Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.

[This corrects the article DOI: 10.1371/journal.pmed.

Road runoff management using over-the-shoulder infiltration: real-scale experimentation.

A new management policy regarding road runoff was proposed in 2002 by the Swiss Federal Office for the Environment (FOEN). This new concept is based on the diffuse infiltration of road runoff into embankment slopes, where soils will filter particles and contaminants. The shoulder lying between road surface and infiltration slopes must be impervious in order to maximise the amount of water reaching the slope and avoid losses in the road structure.

The diffuse infiltration of road runoff: an environmental improvement.

The Laboratory of Engineering and Environmental Geology (GEOLEP) has been mandated by Swiss authorities (Swiss Federal Road Office FedRO) to test a new road runoff management concept. This concept promotes the diffuse infiltration of road runoff into infiltration slopes designed for this purpose. Soils retain particles and contaminants; this lowers the road impact on the environment and simultaneously improves aquifer recharge.