Primary oral vaccination followed by a vaginal pull protects mice against genital HSV-2 infection.

Problem: HSV-2 infected more than 491 million people aged 15-49 world-wide in 2016. The morbidity associated with recurrent infections and the increased risk of HIV infection make this a major health problem. To date there is no effective vaccine.

Phylodynamic signatures in the emergence of community-associated MRSA.

Community-associated, methicillin-resistant (MRSA) lineages have emerged in many geographically distinct regions around the world during the past 30 y. Here, we apply consistent phylodynamic methods across multiple community-associated MRSA lineages to describe and contrast their patterns of emergence and dissemination. We generated whole-genome sequencing data for the Australian sequence type (ST) ST93-MRSA-IV from remote communities in Far North Queensland and Papua New Guinea, and the Bengal Bay ST772-MRSA-V clone from metropolitan communities in Pakistan.

The Ecology and Evolution of Japanese Encephalitis Virus.

Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus mainly spread by mosquitoes that currently has a geographic distribution across most of Southeast Asia and the Western Pacific. Infection with JEV can cause Japanese encephalitis (JE), a severe disease with a high mortality rate, which also results in ongoing sequalae in many survivors. The natural reservoir of JEV is ardeid wading birds, such as egrets and herons, but pigs commonly play an important role as an amplifying host during outbreaks in human populations.

Specialty Probation Officers as Street-Level Bureaucrats: Exploring How Discretion Is Perceived and Employed on a Mental Health Caseload.

This study explores the perceptions of specialty mental health caseload probation officers and their use of discretion in day-to-day supervision of individuals with mental illness in one large jurisdiction in the United States. Scholars have examined overall effectiveness of specialty probation programs, probation officers' roles as street-level bureaucrats, and the impact of the mental health caseload probation officer and probationer relationship on successful completion. Less attention, however, has been placed on examining how the officers supervising these specialty caseloads perceive their roles as mental health probation officers and how they use discretion in their caseload management.

In-Situ Surface Modification of Terpinen-4-ol Plasma Polymers for Increased Antibacterial Activity.

Surface modification of thin films is often performed to enhance their properties. In this work, in situ modification of Terpinen-4-ol (T4) plasma polymer is carried out via simultaneous surface functionalization and nanoparticle immobilization. Terpinen-4-ol plasma polymers surface were decorated with a layer of ZnO nanoparticles in an oxygen plasma environment immediately after polymer deposition.