Factors that influence the quality of the clinical supervision experience in a first contact physiotherapy (FCP) role - The perspectives of supervisors and supervisees - A qualitative analysis.

Purpose: First contact practitioner (FCP) roles have been developed to supplement the primary care workforce in managing the burden of musculoskeletal conditions. In order to quality assure and standardise capability of these clinicians an educational framework was developed by NHS England. The Roadmap to Practice (2020) was the curriculum designed to support and develop capability for FCP roles.

Higgs-induced screening mechanisms in scalar-tensor theories.

We consider the theory of a light conformally coupled scalar field, that is, one that is coupled directly to the Ricci scalar of the gravitational sector. This theory can be written equivalently as one of a light scalar that is coupled to the Standard Model of particle physics with a particular combination of Higgs-portal couplings. When the conformal coupling function contains terms that are linear and quadratic in the conformally coupled scalar, we find that the effective mass of the light propagating mode and its coupling to matter fields, obtained after expanding around a minimum of the classical potential, depend on the energy density of the background environment.

Expanding the phenotype of DYNC1H1-associated diseases with a rare variant resulting in spinal muscular atrophy with lower extremity predominance (SMA-LED) and upper motor neuron signs.

Background: Spinal muscular atrophy with lower extremity predominance (SMA-LED) is an autosomal dominant disorder. Since SMA-LED affects lower motor neurons, the disease is characterized by weakness and atrophy of lower limb muscles. We present a familial case series of SMA-LED with upper motor neuron signs associated with a rare variant in DYNC1H1.

Radiative Screening of Fifth Forces.

We describe a symmetron model in which the screening of fifth forces arises at the one-loop level through the Coleman-Weinberg mechanism of spontaneous symmetry breaking. We show that such a theory can avoid current constraints on the existence of fifth forces but still has the potential to give rise to observable deviations from general relativity, which could be seen in cold atom experiments.

Properties of the periplasmic nitrate reductases from Paracoccus pantotrophus and Escherichia coli after growth in tungsten-supplemented media.

Paracoccus pantotrophus grown anaerobically under denitrifying conditions expressed similar levels of the periplasmic nitrate reductase (NAP) when cultured in molybdate- or tungstate-containing media. A native PAGE gel stained for nitrate reductase activity revealed that only NapA from molybdate-grown cells displayed readily detectable nitrate reductase activity. Further kinetic analysis showed that the periplasmic fraction from cells grown on molybdate (3 microM) reduced nitrate at a rate of V(max)=3.