Publications by authors named "P F Grimes"
Importance: Diverse racial and ethnic representation in clinical trials has been limited, not representative of the US population, and the subject of pending US Food and Drug Administration guidance. Psoriasis presentation and disease burden can vary by skin pigmentation, race and ethnicity, and socioeconomic differences. Overall, there are limited primary data on clinical response, genetics, and quality of life in populations with psoriasis and skin of color (SoC).
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- The study investigates the genetic risk factors associated with different patterns of adolescent depression, highlighting the importance of understanding how genetics contribute to varied symptom trajectories over time.
- Using data from two large longitudinal cohorts in the US and UK, researchers employed growth modeling and polygenic risk score analysis to assess genetic influences on depression and related psychiatric disorders across various ancestries.
- The findings demonstrate unique depression trajectories in adolescents and suggest that genetics play a significant role in the development and progression of depressive symptoms, potentially guiding early intervention strategies.