Publications by authors named "P F Goldsmith"
Article Synopsis
- Diaphragmatic hernias, traditionally linked to birth defects or trauma, can also occur due to surgical procedures, as shown in a rare case involving a 59-year-old woman after pericardial window surgery.
- The patient experienced shortness of breath post-surgery, and imaging revealed an intrapericardial diaphragmatic hernia, leading to an open surgery for repair.
- This case underscores the importance of recognizing and addressing rare complications like these postoperatively, highlighting the need for careful planning and intervention to prevent serious cardiac issues.
Article Synopsis
- - The study investigates the effects of a 2019 kidney offering scheme in the UK on older patients (aged 60+) who received kidney transplants, comparing outcomes before and after the scheme's implementation.
- - Researchers analyzed data from two groups: older adults who had transplants under the old (2006) scheme and those under the new (2019) scheme, focusing on factors like re-intervention and critical care admission.
- - Results indicated that those in the 2019 scheme faced higher odds of needing additional interventions and critical care, as well as less favorable HLA matches and an increase in repeat transplants for patients requiring more complex matching.
Volenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial.
Nephrol Dial Transplant
December 2024
Background: Volenrelaxin is a half-life-extended recombinant human relaxin protein developed for improving kidney perfusion and cardiorenal function. This study assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of volenrelaxin following single- and multiple-ascending doses (SAD and MAD) administration.
Methods: In this Phase 1, four-part, randomized, double-blinded, placebo-controlled SAD and MAD study in healthy participants, SAD participants (n = 56) received an intravenous or subcutaneous dose of volenrelaxin or placebo in a dose-ascending manner.
Peritoneal inclusion cysts (PICs) are a rare and benign condition of uncertain pathogenesis. The fluid-filled, mesothelial-lined cysts manifest within the abdominopelvic cavity. This case report details an unusual occurrence of a 97 mm PIC- presenting as an umbilical hernia- in a 26-year-old male patient with no prior surgical history.
View Article and Find Full Text PDFModelling science return from the lunar crater radio telescope on the far side of the moon.
Philos Trans A Math Phys Eng Sci
May 2024
The era following the separation of CMB photons from matter, until the emergence of the first stars and galaxies, is known as the Cosmic Dark Ages. Studying the electromagnetic radiation emitted by neutral hydrogen having the 21 cm rest wavelength is the only way to explore this significant phase in the Universe's history, offering opportunities to investigate essential questions about dark matter physics, the standard cosmological model and inflation. Due to cosmological redshift, this signal is now only observable at frequencies inaccessible from the Earth's surface due to ionospheric absorption and reflection.
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