Publications by authors named "P F Ells"
Hepatic Langerhans cell histiocytosis (LCH) is characterized by proliferation and accumulation of Langerhans cells in the liver, causing liver dysfunction or forming a mass lesion. The liver can be involved in isolation, or be affected along with other organs. A common clinical hepatic presentation is cholestasis with pruritis, fatigue and direct hyperbilirubinemia.
View Article and Find Full Text PDFLangerhans cell histiocytosis (LCH) is a rare systemic disorder characterized by an infiltration of CD1a+/langerin+ histiocytes, commonly involving bone, skin, and lymph nodes in children. Hepatic involvement is rarely observed in multisystem LCH. We describe an exceptional case of hepatic LCH in an adult preceding the diagnosis of multisystem LCH, mimicking anti-mitochondrial antibody (AMA)-negative primary biliary cholangitis (PBC).
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- - Preoperative hyperbilirubinemia is found in about 10% of patients undergoing transcatheter aortic valve replacement (TAVR) and is more common in younger males and those with certain heart conditions.
- - Patients with elevated bilirubin levels before TAVR have a higher risk of complications post-surgery, including increased rates of death, stroke, and the combination of both.
- - The study highlights that hyperbilirubinemia is linked to worse outcomes in TAVR patients and suggests that this condition may be more common and clinically significant than previously thought.
Kratom is an herbal supplement used to relieve chronic pain or opioid withdrawal symptoms. Recent news articles covering adverse effects associated with kratom use have brought attention to its organ toxicities. Reports of kratom-induced hepatic toxicity are limited and only three case reports of kratom-induced liver injury with histopathologic examination of the liver biopsies are available.
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- Idiopathic noncirrhotic portal hypertension (INCPH) can show specific histologic changes in liver biopsies, even when there's no cirrhosis present.
- In a study of 81 liver biopsies, common features of INCPH were found in a majority of samples, with 90% showing at least one characteristic and 10% displaying multiple features despite normal portal pressure.
- Understanding these histologic features within the correct clinical context is crucial for accurate diagnosis and patient management.