Publications by authors named "P F Daniel"
Pediatric high-grade gliomas (pHGGs) are the most aggressive brain tumors in children, necessitating innovative therapies to improve outcomes. Unlike adult gliomas, recent research reveals that childhood gliomas have distinct biological features, requiring specific treatment strategies. Here, we focused on deciphering unique genetic dependencies specific to childhood gliomas.
View Article and Find Full Text PDFMarine mammal populations, particularly the common dolphin Delphinus delphis in the North-East Atlantic, play an essential role as indicators of ecosystem health. Effective monitoring of these populations is essential for assessing anthropogenic impacts, especially in the context of current threats such as fisheries bycatch. The MOTHY drift model, initially designed for oil spills and then adapted to carcass drift, is being used in part of the North East Atlantic (Bay of Biscay, English Chanel, and North Sea) to estimate the bycatch mortality of common dolphins.
View Article and Find Full Text PDFBackground: With higher valency pneumococcal vaccines on the horizon and new adult immunisation strategies under discussion, we aimed to evaluate the contribution of individual pneumococcal serotypes to the burden of pneumococcal community-acquired pneumonia (CAP). Over 10 years, trends in pneumococcal pneumonia epidemiology in adults hospitalised with CAP were assessed. The risk factors and severity associated with serotype 3 were examined.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma (GBM), an aggressive brain cancer, shows increased production of reactive oxygen species (ROS) and uses antioxidant systems to survive; Auranofin, a drug for rheumatoid arthritis, inhibits a key antioxidant enzyme called thioredoxin reductase 1 (TrxR1), leading to cell death in GBM stem cells (GSCs).
- A study found that combining Auranofin with other inhibitors like L-buthionine sulfoximine (L-BSO) and piperlongumine (PPL) significantly enhances the drug's effectiveness, increasing ROS levels and reducing toxicity thresholds in GBM cell lines regardless of p53 status.
- The research indicates potential for repurposing A
Background: The study evaluated the prognostic impact of the immune microenvironment in LSCC with markers of major immune cells to identify the key determinants of short-term disease-free survival (ST DFS) and reveal factors related to disease progression.
Methods: The study cohort included 61 patients who underwent total laryngectomy, 83.6% of whom were male with a mean age of 64.