Publications by authors named "P F Danek"
Article Synopsis
- WBP1L (also known as OPAL1) is a protein linked to better outcomes in childhood leukemia and is involved in regulating hematopoiesis and CXCR4 signaling.
- Mice lacking WBP1L show dysregulated hematopoiesis, with enlarged thymi and increased thymocyte counts, likely due to the enhancement of multipotent progenitors in the bone marrow.
- The study highlights WBP1L's role in maintaining hematopoietic stem cell functionality, influencing leukocyte progenitor growth, and improving outcomes during stem cell transplants.
Article Synopsis
- Research into the innate immune system's role in health and disease is growing, highlighting the need for suitable mouse models for reliable in vivo studies.
- Genetic differences across mouse strains, like BALB/c and C57BL/6, significantly influence how the diseases manifest, particularly relating to immune responses.
- A study of chronic multifocal osteomyelitis (CMO) in various strains revealed that the genetic background affects disease severity, immune cell activity, and the overall inflammation response.
Article Synopsis
- The vegetation history of semi-dry grasslands in Central Europe is complex, with current species diversity potentially stemming from long-standing open landscapes or past forested phases.
- Detailed studies were conducted on soil samples to analyze carbon and nitrogen content, lipid distribution, and stable isotopes from various plant materials.
- Findings indicate a significant contribution of C3 trees to soil organic matter during the late Pleistocene to early Holocene, with a notable transition to grassy and herbaceous vegetation occurring from the early Holocene onwards.
Background: Our recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome P450 (CYP), as demonstrated in vitro on human hepatocytes and in vivo on the rat liver. The aim of the present work was to study the effect of repeated treatment with asenapine, iloperidone, and lurasidone on the expression of transcription factors regulating CYP drug-metabolizing enzymes in rat liver.
Methods: The hepatic mRNA (qRT-PCR) and protein levels (Western blotting) of aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPARγ) were measured in male Wistar rats after 2 week-treatment with asenapine, iloperidone or lurasidone.