Publications by authors named "P Esposito"
Adiponectin removal by the human kidney: A preliminary study.
Nutr Metab Cardiovasc Dis
November 2024
Background And Aims: The adipocyte-derived adiponectin (APN) has potent insulin-sensitizing and anti-inflammatory properties. The adipose tissue is known to be the main source for APN in the circulation, but sites and mechanisms which remove APN from blood are still unknown in humans.
Methods And Results: We reviewed APN data obtained in previous studies in which the inter-organ exchange of amino acids and cytokines was measured in our laboratory.
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic malignancies, yet it carries significant risks, including acute kidney injury (AKI). In this study, we investigated the risk factors and clinical impact of AKI in patients undergoing CAR-T cell therapy. This retrospective study involved hematologic patients treated with CAR-T therapy.
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- * In this study, human kidney cells exposed to both polyethylene microplastics and BPA showed decreased cell viability and increased pro-oxidant and pro-inflammatory responses compared to those exposed to either substance alone.
- * Additionally, the research found that exposure reduced levels of heat shock protein (HSP90) while increasing aryl hydrocarbon receptor (AHR) expression, highlighting the need for further investigation into how these pollutants interact and affect kidney health.