Publications by authors named "P Einat"
Context: Immigrants from the former Union of Soviet Socialist Republics (USSR) are more prevalent in Methadone maintenance treatment (MMT) in Israel than their percentage in the general population.
Aims: To compare their characteristics and outcomes to those of Israeli-born and other immigrant patients.
Methods: Retention and survival since admission (June/1993-Dec/2022) until leaving treatment (for retention), or at the end of follow-up were analyzed.
Article Synopsis
- Opioid use disorder (OUD) is a growing public health issue in Israel, prompting a study to evaluate physicians' knowledge, stigma, and prescribing practices related to opioids and substance use disorder (SUD).
- A national survey of 249 physicians revealed that those with greater knowledge were more likely to encounter SUD patients and were well-informed about opioid maintenance treatment (OMT).
- The study found that higher stigma levels were linked to opioid prescribing and limited knowledge about OMT, indicating a need for educational interventions to reduce stigma and improve patient referrals for effective OUD treatment.
Small-interfering RNAs and microRNAs are small ∼21-22 nucleotide long RNAs capable of posttranscriptional suppression of gene expression. The synthetic siRNAs are especially designed to target pre-specified genes and are common molecular biology tools. The miRNAs are endogenous regulators of gene expression found in a wide variety of eukaryotes.
View Article and Find Full Text PDFUncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative phosphorylation. Upon cold exposure or nutritional abundance, sympathetic neurons stimulate BAT to express Ucp1 to induce energy dissipation and thermogenesis. Accordingly, increased Ucp1 expression reduces obesity in mice and is correlated with leanness in humans.
View Article and Find Full Text PDFWe report on the construction of a leptin bioassay based on the activation of chicken leptin receptor in cultured cells. A human embryonic kidney (HEK)-293 cell line, stably transfected with the full-length cDNA of chicken leptin receptor together with a STAT3-responsive reporter gene specifically responded to recombinant human and Xenopus leptins. The observed higher sensitivity of chicken leptin receptor to the former is in agreement with the degree of sequence similarity among these species (about 60 and 38% identical amino acids between humans and chickens, and between humans and Xenopus respectively).
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