Publications by authors named "P Eftekhari"
Article Synopsis
- - Multiple myeloma (MM) is a type of cancer that affects plasma cells and can cause severe complications like anemia, bone damage, high calcium levels, and kidney issues.
- - Cases of low complement levels in patients with MM and kidney failure are rare, as low complements are usually linked to other kidney diseases.
- - This report highlights an unusual case of a patient with MM who experienced acute kidney injury and low complement levels, suggesting that doctors should consider MM when diagnosing kidney issues.
The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750-800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046-2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12).
View Article and Find Full Text PDFArticle Synopsis
- Drug repurposing offers new therapeutic options by exploring existing medications, with "Drug Upgrade" being a proposed method to identify new uses.
- The study focused on hydroxychloroquine (HCQ), known for its effectiveness in lupus but also its side effect of retinal toxicity.
- Researchers identified specific targets of HCQ through advanced techniques, developed a new compound, INS-072, which showed better efficacy and fewer side effects in lupus models compared to HCQ.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis comprises several conditions involving vascular destruction that extends into tissue necrosis. There are several autoimmune and environmental causes implicated in the disease progression; among these is drug-induced vasculitis caused by hydralazine use. Hydralazine-induced vasculitis is an uncommon potential complication of the medication and can progress to multisystem involvement and eventually advance to end-organ damage and renal failure.
View Article and Find Full Text PDFBackground: Medication adherence is a crucial component of the pharmacological treatment of smoking. Previous interventions targeted to improve adherence to smoking cessation medications (SCMs) were designed using pragmatic approaches. This study aims to develop a comprehensive intervention strategy to improve adherence to SCMs using the Behaviour Change Wheel (BCW) and a modified Delphi method.
View Article and Find Full Text PDF