Publications by authors named "P Eckert"
One of the seven natural CO fixation pathways, the anaerobic Wood-Ljungdahl pathway (WLP) is unique in generating CO as a metabolic intermediate, operating through organometallic intermediates, and in conserving (versus utilizing) net ATP. The key enzyme in the WLP is acetyl-CoA synthase (ACS), which uses an active site [2Ni-4Fe-4S] cluster (A-cluster), a CO tunnel, and an organometallic (Ni-CO, Ni-methyl, and Ni-acetyl) reaction sequence to generate acetyl-CoA. Here, we reveal that an alcove, which interfaces the tunnel and the A-cluster, is essential for CO fixation and autotrophic growth by the WLP.
View Article and Find Full Text PDFInversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation.
Biochem Biophys Res Commun
September 2023
Nephronophthisis (NPH), an autosomal recessive ciliopathy, results from mutations in more than 20 different genes (NPHPs). These gene products form protein complexes that regulate trafficking within the cilium, a microtubular structure that plays a crucial role in developmental processes. Several NPHPs, including NPHP2/Inversin, have been linked to extraciliary functions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between hearing loss and dementia, focusing on how the brain compensates for reduced auditory input following cochlear synaptopathy.
- It found that individuals with low central compensation had poorer auditory processing and less hippocampal long-term potentiation (LTP), while those with high compensation exhibited better auditory processing and greater LTP.
- The research highlighted that variables such as corticosterone levels and stress responses could influence the brain's ability to compensate for hearing loss and maintain auditory function.
The zebrafish pronephros model, using morpholino oligonucleotides (MO) to deplete target genes, has been extensively used to characterize human ciliopathy phenotypes. Recently, discrepancies between MO and genetically defined mutants have questioned this approach. We analyzed zebrafish with mutations in the nphp1-4-8 module to determine the validity of MO-based results.
View Article and Find Full Text PDFObjective: We aimed to assess if emergency department (ED) syndromic surveillance during the first and second waves of the COVID-19 outbreak could have improved our surveillance system.
Design And Settings: We did an observational study using aggregated data from the ED of a university hospital and public health authorities in western Switzerland.
Participants: All patients admitted to the ED were included.