Publications by authors named "P Eagle"

Article Synopsis
  • The joint College of American Pathologists and American College of Medical Genetics and Genomics aims to improve the identification of chromosomal abnormalities in various specimens, especially hematologic neoplasms.
  • A study covering 20 years (1999-2018) evaluated 288 chromosome challenges, focusing on those related to hematologic neoplasms, with 91 cases graded for abnormality recognition and karyotype nomenclature.
  • Results show that the majority of laboratories performed well, with over 95% achieving the required consensus, although a few cases encountered challenges due to complex karyotypes and errors in recognition or nomenclature.
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The mechanisms of injury of the human neck are potentially related to the forces and bending moments acting on the spinal column. An injury criterion that combines the effects of the time history of force and moment, N(ij), has been adopted by the USA federal government for vehicle crash regulations. This paper presents two analytical approaches to evaluate the N(ij) injury criterion using previously published biomechanical data: a direct fit optimization analysis and a statistical analysis.

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Geminiviruses are DNA viruses that replicate and transcribe their genes in plant nuclei. They are ideal vectors for understanding plant gene function because of their ability to cause systemic silencing in new growth and ease of inoculation. We previously demonstrated DNA episome-mediated gene silencing from a bipartite geminivirus in Nicotiana benthamiana.

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This study compared 21 female adult psychiatric patients diagnosed with dissociative identity disorder (DID) with 21 female adult nondissociative psychiatric patients to determine whether DID patients exhibit a distinguishing set of clinical features, and perceptual, attentional, and cognitive processes. Participants were assessed with the Dissociative Disorders Interview Schedule to assess diagnostic status. Group scores on the Dissociative Experiences Scale, Tellegen Absorption Scale, Childhood Trauma Questionnaire, Brief Symptom Inventory, and the Rorschach test were compared.

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The genome of the geminivirus tomato golden mosaic virus (TGMV) consists of two circular DNA molecules which are dissimilar in sequence except for a highly conserved 200-bp common region that includes the origin for rolling circle replication. To better characterize the plus-strand origin, we analyzed the capacities of various TGMV common region sequences to support episomal replication in tobacco protoplasts when the viral replication proteins AL1 and AL3 were supplied in trans. These experiments demonstrated that the minimal origin is located in 89-bp common region fragment that includes the known AL1 binding motif and a hairpin structure containing the DNA cleavage site.

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