Adverse childhood experiences and loneliness: A systematic review and meta-analysis.

Adverse childhood experiences are considered a powerful determinant of emotional health. One indicator of emotional health is loneliness, which refers to a distressing experience that one's social relationships are less in quality and quantity than those desired. This preregistered review aimed to examine the association between adverse childhood experiences (e.

Mesdopetam for the Treatment of Levodopa Induced Dyskinesia in Parkinson's Disease: A Randomized Phase 2b Trial.

Background: The treatment of levodopa-induced dyskinesia in Parkinson's disease (PD) is a largely unmet need.

Objectives: Mesdopetam is a novel small molecule dopamine D3 receptor antagonist aimed for the treatment of levodopa-induced dyskinesia. This was a phase 2b study dose finding study to investigate efficacy and safety of 2.

Loneliness links Adverse Childhood Experiences to Mortality Risk across 26 years.

Objectives: Adverse Childhood Experiences (ACEs) are associated with increased mortality risk. Individuals with a history of certain adversity during childhood tend to report higher levels of loneliness in later life. In our pre-registered study, we examined whether loneliness mediates the ACEs to mortality risk relation.

Loneliness and cognition in older adults: A meta-analysis of harmonized studies from the United States, England, India, China, South Africa, Mexico, and Chile.

Background: Loneliness is a risk factor for late-life dementia. There is less consistent evidence of its association with cognitive performance. This study examined the replicability of the association between loneliness and overall and domain-specific cognitive function and informant-rated cognitive decline in cohorts from seven countries: the United States, England, India, China, South Africa, Mexico, and Chile.

Audible tremor: Analysis of the validity of audible information in assessing tremor severity.

Introduction: Assessing the severity of kinetic tremor is important in clinical and research settings. Archimedes spirals are often used to assess tremor severity. Rating tremor from spirals has been based solely on visual information.