Publications by authors named "P E Kovanen"
Since the discovery of statins and the Scandinavian Simvastatin Survival Study (4S) results three decades ago, remarkable advances have been made in the treatment of dyslipidaemia, a major risk factor for atherosclerotic cardiovascular disease. Safe and effective statins remain the cornerstone of therapeutic approach for this indication, including for children with genetic dyslipidaemia, and are one of the most widely prescribed drugs in the world. However, despite the affordability of generic statins, they remain underutilised worldwide.
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- * After treatment with PCSK9 inhibitors, plasma from FH patients showed altered cholesterol distribution, with less cholesterol in LDL and more in HDL.
- * PCSK9 inhibitors enhanced the movement of cholesterol to feces in specific mouse models and support the reverse cholesterol transport pathway in patients with heterozygous FH.
The risk of atherosclerotic cardiovascular diseases (ASCVDs) can be reduced by lowering low-density lipoprotein cholesterol (LDL-C) concentrations. Nevertheless, ASCVDs still cause most deaths worldwide. Here, we discuss the prevention of ASCVD and the event risk with a focus on heart-healthy diets, i.
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