Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease.

The treatment of complex and multifactorial diseases constitutes a big challenge in day-to-day clinical practice. As many parameters influence clinical phenotypes, accurate diagnosis and prompt therapeutic management is often difficult. Significant research and investment focuses on state-of-the-art genomic and metagenomic analyses in the burgeoning field of Precision (or Personalized) Medicine with genome-wide-association-studies (GWAS) helping in this direction by linking patient genotypes at specific polymorphic sites (single-nucleotide polymorphisms, ) to the specific phenotype.

Information seeking behavioural paths of physicians for diabetes mellitus care: a qualitative comparative analysis of information needs, sources, and barriers.

This study addresses diabetes physicians' information seeking behavioural paths (digital, conventional, interpersonal) which lead to information needs satisfaction and the barriers encountered in this process. The study was based on empirical evidence from a survey of 159 physicians. Theoretical analysis was informed by Wilson's model of information seeking behaviour.

Online information search behaviour of physicians.

Background: Although doctors increasingly engage in online information seeking to complement their medical practice, little is known regarding what online information sources are used and how effective they are.

Objective: Grounded on self-determination and needs theory, this study posits that doctors tend to use online information sources to fulfil their information requirements in three pre-defined areas: patient care, knowledge development and research activities. Fulfilling these information needs is argued to improve doctors' perceived medical practice competence.

Exploring the online satisfaction gap of medical doctors: an expectation-confirmation investigation of information needs.

This research explores the satisfaction gap between the expectations of medical doctors when using the Internet to search for health-related information, and the confirmations they receive following the use of specific information sources to meet their information needs. We executed a quantitative study on 303 medical doctors to capture their online information-seeking behavior. Results suggest that authoritative online information sources are strongly related with the derived satisfaction of medical doctors' online information needs, whilst expectation fulfillment is not related with usage of non-authoritative sources.