Publications by authors named "P E Kaplan"
Purpose: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune reaction involving Immunoglobulin G antibodies against GluN1 subunit of NMDAR. Absence of biomarkers for early diagnosis and prognosis poses a challenge. Several small case-control studies have emphasized the prospect of quantitative EEG measurements.
View Article and Find Full Text PDFObjective: CT hyper-perfusion has been reported in non-convulsive status epilepticus (NCSE), while its occurrence and relevance after single seizures or with rhythmic and periodic patterns (RPPs) that lie along the ictal-interictal continuum (IIC), remain unclear. The goal of the study is to assess the role of CT perfusion (CTP) in diagnosing patients with clinical seizures, subclinical seizures, or RPPs that lie along the IIC, to help in the clinical assessment of these entities.
Methods: We retrospectively reviewed inpatients who underwent a CTP and an EEG within 6 h of each other.
Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
November 2024
Background And Objectives: Recent studies suggest that the choroid plexus (CP) may function as a site of access of inflammatory cells into the CNS in multiple sclerosis (MS). Pediatric-onset MS (POMS) is characterized by a high inflammatory burden, as evidenced by a high relapse rate and volume of T2 lesions, making patients with POMS an informative population to evaluate choroid plexus volume (CPV). The objectives of the study were (1) to evaluate CPV at symptom onset in participants with POMS compared with healthy controls (HCs); (2) to evaluate changes in CPV in the first year of disease in participants with POMS; and (3) to evaluate associations between CPV, brain volumes, relapse activity, and disability in participants with POMS.
View Article and Find Full Text PDFArticle Synopsis
- Electroencephalographic reactivity (EEG-R) is highlighted as a potential early indicator of arousal in comatose patients following cardiac arrest, which could help inform prognosis.
- Current EEG-R testing methods vary significantly across different studies, despite recent initiatives aimed at standardizing these practices to minimize inconsistencies in results.
- The review emphasizes the need for further research to understand the neurophysiological mechanisms behind EEG-R and its implications for improving patient care and ongoing research in the field.
Article Synopsis
- * The study identified 22 proteins with altered levels in heart homogenates of rats with chronic mild HHcy, highlighting their roles in energy metabolism, cardiac function, stress response, and antioxidant defense.
- * Findings showed decreased antioxidant defenses and increased oxidative damage, suggesting that both altered protein expression and oxidative stress contribute to heart damage in HHcy.