Development and Psychometric Validation of a Patient-Reported Outcome Measure to Assess the Signs and Symptoms of Chronic Hand Eczema: The Hand Eczema Symptom Diary (HESD).

Introduction: Chronic Hand Eczema (CHE) is an inflammatory skin disease of the hands. The Hand Eczema Symptom Diary (HESD) is a new patient-reported outcome measure of worst severity of core CHE signs/symptoms. This study aimed to evaluate content and psychometric validity of the HESD.

A novel antiangiogenic approach for adjuvant therapy of pancreatic carcinoma.

Introduction: Surgical therapy remains the only curative option for pancreatic ductal adenocarcinoma. But even after complete resection, almost all patients suffer from local tumor recurrence. Current standard adjuvant therapy with gemcitabine does not impressively affect the recurrence rate.

Functional analysis of LOXL2 in pancreatic carcinoma.

Objectives: Lysyl oxidase-like 2 (LOXL2) plays a part in epithelial-mesenchymal transition (EMT) by stabilizing the transcription factor SNAI1. Previous studies showed that LOXL2 is one of the most highly and specifically upregulated genes in pancreatic cancer. LOXL2 was also found to be strongly upregulated in the secretome of established pancreatic cancer cell lines.

[Pulmonary sequestration - a case report and review of the litterature.].

Pulmonary sequestration is an uncommon congenital malformation where non-functioning lung tissue is separated from the normal bronchopulmonary tree and vascularized by an aberrant systemic artery. We describe a previously healthy 17 year old girl who was diagnosed with intralobar sequestration following a pneumonia and pulmonary abscess. The diagnosis was made with on CT-scan and confirmed by MRI angiography.