Publications by authors named "P E Hesterberg"
Data regarding response to SARS-CoV-2 immunization in pediatric patients with predominantly antibody deficiency (PAD) is limited. We evaluated SARS-CoV-2 immunization response by anti-SARS-CoV-2-spike antibody level in 15 pediatric PAD patients. These data were compared to a published cohort of adult PAD patients (n=62) previously analyzed following SARS-CoV-2 immunization at our single center institution.
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- Patients with predominant antibody deficiency (PAD) exhibit a significantly lower antibody response to SARS-CoV-2 vaccines compared to healthy controls, especially those with severe PAD conditions.
- Factors contributing to poor immune response include low levels of specific T and B cells, and prior B-cell depletion therapy.
- Administering an additional dose of mRNA vaccine significantly boosts antibody levels in PAD patients, indicating potential for improved immunity.
Background: Massachusetts began newborn screening (NBS) for severe combined immunodeficiency (SCID) using measurement of T-cell receptor excision circles (TRECs) from dried blood spots.
Objective: We describe developments and outcomes from the first 10 years of this program (February 1, 2009, to January 31, 2019).
Methods: TREC values, diagnostic, and outcome data from all patients screened for SCID were evaluated.
Background: Although almond specific IgE-mediated food allergies have traditionally been equated with other tree nut allergies, outcomes of oral food challenges to almond and the utility of clinical testing to predict IgE-mediated almond hypersensitivity are not well known.
Objective: To describe almond oral challenge outcomes and assess the predictive value of clinical testing.
Methods: A total of 603 almond challenges performed for 590 patients, aged 1 to 66 years, were analyzed from Massachusetts General Hospital allergy practices.