Publications by authors named "P E De-Los-Rios"
One of the hypothesized functions of biomolecular condensates is to act as chemical reactors, where chemical reactions can be modulated, i.e., accelerated or slowed down, while substrate molecules enter and products exit from the condensate.
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- - Hsp70 chaperones play a key role in maintaining protein quality by assisting in processes like disaggregation and translocation into organelles, but their exact mechanism has been a topic of debate with no experimental proof for existing models.
- - Using nanopores as a tool, researchers discovered that Hsp70s can pull out trapped polypeptides by generating strong forces, confirming the Entropic Pulling mechanism as the explanation for their action.
- - The study not only resolves ongoing questions about Hsp70 functions but also emphasizes the potential of biological nanopores for advancing protein research.
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- The SOLAR study compared the effectiveness of a long-acting injection treatment (CAB + RPV LA) to a daily oral regimen (BIC/FTC/TAF) for HIV over 12 months, showing that the injection was just as effective in managing the virus.
- Out of 670 participants, those who switched to CAB + RPV LA reported significantly higher treatment satisfaction and better mental health outcomes compared to those who continued with BIC/FTC/TAF.
- 90% of participants preferred the long-acting injection, indicating a positive shift in perceptions regarding HIV treatment by reducing psychological challenges associated with daily medication regimens.
Living systems are maintained out of equilibrium by external driving forces. At stationarity, they exhibit emergent selection phenomena that break equilibrium symmetries and originate from the expansion of the accessible chemical space due to nonequilibrium conditions. Here, we use the matrix-tree theorem to derive upper and lower thermodynamic bounds on these symmetry-breaking features in linear and catalytic biochemical systems.
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