Publications by authors named "P E Cippa"
Article Synopsis
- JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare condition impacting kidney transplant functions, with limited documented cases.
- Two cases were presented involving patients who developed JC-PVAN more than five years after their kidney transplants, showing specific kidney damage during biopsies.
- Despite initiating immunosuppressive therapy, both cases experienced a continued decline in kidney function, highlighting the need for thorough diagnostics when graft dysfunction occurs long after transplantation.
Article Synopsis
- Kidney structural cells actively participate in the rejection process of kidney transplants, alongside infiltrated immune cells, as shown through single-cell RNA sequencing of biopsies.
- Upregulation of immune-related genes was observed in endothelial and epithelial cells, indicating their involvement in the alloimmune response, with distinct differences based on the kidney compartment.
- A significant downregulation of energy metabolism in proximal tubular cells during inflammation correlates with reduced kidney function, emphasizing the graft's crucial role in driving and maintaining rejection after transplantation.
Aims: Diuretic resistance (i.e., insufficient diuretic and natriuretic response to an appropriate dose of intravenously administered loop diuretic) is a major cause of insufficient decongestion in acute heart failure (AHF).
View Article and Find Full Text PDFBackground: Taurine is one of the most abundant amino acids in humans. Low taurine levels are associated with cellular senescence, mitochondrial dysfunction, DNA damage, and inflammation in mouse, all of which can be reversed by supplementation. It is unknown whether taurine metabolism is associated with kidney allograft function and survival.
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