Publications by authors named "P E Bonnot"

Objective: Negative-pressure wound therapy for open abdomen (NPWTOA) helps reduce the risk of abdominal compartment syndrome. However, the risk of recurrence of cancer is unclear when NPWTOA is applied after oncologic resection. The aim of this study was to evaluate the effects of NPWTOA used for major complications on patients treated with cytoreductive surgery for peritoneal malignancy (PM).

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Background: Gastric cancer (GC) is associated with a poor prognosis mostly due to peritoneal metastasis, which will develop in time during the patient's disease history. To prevent and treat peritoneal metastasis, different kinds of treatment regimens have been described.

Summary: In this review, we addressed two main topics - prophylaxis and treatment of peritoneal metastasis in GC.

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Article Synopsis
  • Peritoneal carcinomatosis from appendiceal goblet cell carcinoma (A-GCC) is a rare and aggressive cancer, and this study investigated the effectiveness of cytoreductive surgery (CRS) combined with hyperthermic intra peritoneal chemotherapy (HIPEC) as a treatment option.
  • The analysis of 83 patients showed a median overall survival of 34.6 months, with better outcomes for those receiving complete CRS compared to incomplete CRS; complete CRS patients had a 5-year survival rate of 44%.
  • While CRS and HIPEC may improve long-term survival for A-GCC patients, further research is necessary to determine whether it should be considered the gold standard treatment.
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Background And Objectives: The prognosis of patients undergoing kidney tumor resection or kidney donation is linked to many histologic criteria. These criteria notably include glomerular density, glomerular volume, vascular luminal stenosis, and severity of interstitial fibrosis/tubular atrophy. Automated measurements through a deep-learning approach could save time and provide more precise data.

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Background: The incidence of gastric poorly cohesive carcinoma (PCC) is increasing. The prognosis for patients with peritoneal metastases remains poor and the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is controversial. The aim was to clarify the impact of gastric PCC with peritoneal metastases treated by CRS with or without HIPEC.

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