Publications by authors named "P Dundr"
Extrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Despite its morphological similarity to lung small cell carcinomas, its oncogenesis remains uncertain. One hundred and seventy-one EP-SCNC were enrolled in a multicenter study, and all tissue samples underwent an immunohistochemical p53 analysis.
View Article and Find Full Text PDFLow-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological features with other uterine mesenchymal tumors. Misdiagnosis rates remain significant, and immunohistochemical data for LG-ESS are limited to small series and inconsistent antibody panels. This study aimed to refine the IHC profile of LG-ESS by analyzing a large, molecularly confirmed series of 147 cases using a panel of 24 antibodies, including newer markers like transgelin and smoothelin.
View Article and Find Full Text PDFExtrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Most patients with EP-SCNC have metastatic disease upon presentation, and their average overall survival (OS) is less than 12 months. Our study aimed to conduct a complex analysis of EP-SCNC.
View Article and Find Full Text PDFBackground: Juvenile granulosa cell tumor (JGCT) of the ovary is a rare tumor with distinct clinicopathological and hormonal features primarily affecting young women and children. We conducted a complex clinicopathological, immunohistochemical, and molecular analysis of five cases of JGCT.
Methods: The immunohistochemical examination was performed with 32 markers, including markers that have not been previously investigated.
Article Synopsis
- - Uterine sarcomas with KAT6B/A::KANSL1 fusion are a new type of tumor that show a mix of traits from low-grade endometrial stromal sarcomas and smooth muscle tumors, which can confuse initial diagnoses.
- - A study involving 9 such cases found common features like expression of smooth muscle and endometrial stromal markers, as well as the presence of the KAT6B/A::KANSL1 fusion in all tumors.
- - Despite their bland appearance, these tumors can be aggressive, with some patients experiencing severe outcomes, underscoring the need for accurate recognition and diagnosis for better treatment approaches.