Preventive efficacy of six monthly doses of NexGard® PLUS or Simparica Trio® against a macrocyclic lactone-resistant isolate (JYD-34) of Dirofilaria immitis and of a single dose of NexGard PLUS against a susceptible isolate.

Background: Two studies were conducted assessing the efficacy of NexGard® PLUS (NP) in preventing heartworm disease. Study 1 evaluated the efficacy of six monthly doses of NP or Simparica Trio® (ST) against a macrocyclic lactone-resistant isolate of heartworm, Dirofilaria immitis, and study 2 evaluated the efficacy of a single dose of NP against a susceptible isolate.

Methods: In two studies, dogs that were negative for heartworms by antigen test and modified Knott's test were used.

Modelling acoustic propagation in realistic ocean through a time-domain environment-resolving ocean model.

The new generation of non-hydrostatic and compressible numerical models of the ocean can explicitly simulate acoustic waves when and where space and time resolution is adapted. We show that these models can consequently propagate accurately acoustic waves and modes through a free-surface, stratified ocean evolving simultaneously both in space and time, bringing them to the state of the art of acoustic propagation modelling. To some extent, both numerical cost and memory footprint may temper their range of applications but they are an unprecedented tool to evaluate deterministically the effects of ocean variability on low-frequency acoustic propagation in a realistically-evolving ocean.

COVID-19 among lung cancer patients: Data from a real-life prospective French multicentric study.

Background: COVID-19 started to spread early in 2020, the precise year that lung cancer (LC) patients were recruited into the prospective epidemiological cohort KBP-2020-CPHG in French hospitals. This provides a unique opportunity to study COVID-19 incidence, survival risk factors, and overall prognosis.

Methods: COVID data was collected before vaccination was made available.

An in-hospital intervention to reduce the proportion of misused inhalers at hospital discharge among patients with COPD: a non-randomised intervention study.

Aims Of The Study: Misuse of inhalers during chronic obstructive pulmonary disease (COPD) treatment is common and may result from errors in inhalation technique or insufficient peak inspiratory flow (PIF). We aimed to evaluate the impact of an in-hospital intervention to reduce inhaler misuse at hospital discharge among patients with COPD.

Methods: We conducted a monocentric, non-randomised intervention study to compare the proportion of misused inhalers at hospital discharge by patients with COPD between a group with standard care and a group receiving an in-hospital intervention.

A numerical approach to model sound generation by ocean dynamical processes: The case of surface gravity waves.

The new generation of regional ocean models can provide the evolution of both the slow and fast components of pressure, consequently opening original opportunities to evaluate the acoustic signal generated by ocean slower dynamical processes. This capacity is evaluated in the case of surface waves, with a focus on the hydro-acoustic precursors and on the acoustic modes induced by supersonic surface wave groups. The consistency with theory confirms that such models are adapted to answer recent interrogations by Wunsch [(2022).