Publications by authors named "P Diebold"
The exchange of mobile genetic elements (MGEs) facilitates the spread of functional traits including antimicrobial resistance within bacterial communities. Tools to spatially map MGEs and identify their bacterial hosts in complex microbial communities are currently lacking, limiting our understanding of this process. Here we combined single-molecule DNA fluorescence in situ hybridization (FISH) with multiplexed ribosomal RNA-FISH to enable simultaneous visualization of both MGEs and bacterial taxa.
View Article and Find Full Text PDFThe gut microbiome possesses numerous biochemical enzymes that biosynthesize metabolites that impact human health. Bile acids comprise a diverse collection of metabolites that have important roles in metabolism and immunity. The gut microbiota-associated enzyme that is responsible for the gateway reaction in bile acid metabolism is bile salt hydrolase (BSH), which controls the host's overall bile acid pool.
View Article and Find Full Text PDFThe gut microbiome possesses numerous biochemical enzymes that biosynthesize metabolites that impact human health. Bile acids comprise a diverse collection of metabolites that have important roles in metabolism and immunity. The gut microbiota-associated enzyme that is responsible for the gateway reaction in bile acid metabolism is bile salt hydrolase (BSH), which controls the host's overall bile acid pool.
View Article and Find Full Text PDFArticle Synopsis
- Pneumothorax (PTX) is a rare but serious condition in neonates, with an overall incidence of 0.56 per 100 births, varying between hospitals; treatment methods included conservative care, chest tube drainage, and needle aspiration.
- Among the treatment options, needle aspiration had a higher failure rate (37%) compared to chest tube drainage (9%), yet it resulted in fewer X-rays and shorter hospital stays (2 days vs 6 days).
- The study proposes a new management algorithm to standardize PTX treatment across different hospitals in the network, aiming to improve outcomes while considering the variability of incidence rates.
Article Synopsis
- * A study of 14,850 human and 1,666 environmental metagenomes revealed that certain concerning AR genes, such as CTX-M and various carbapenemases, are mostly restricted to specific bacteria like Proteobacteria and Bacteroides.
- * Despite the ability of some AR genes to adapt between different bacterial groups, they have not widely spread within diverse gut microbiota, suggesting a limited transfer of clinically relevant resistance traits.